MM-CA4(b)-S2 Neurophysiologie cognitive de la perception


Course content:

The aim of this UE is to introduce the audience with classical and cutting edge research articles focusing on the neurophysiology of decision-making. We will focus on the interplay between bottom-up and top-down factors during the selection of relevant information. The emphasis will be on electrophysiological recordings across multiple areas (from sensory to frontal cortices) in behaving animals. Each week a student will present one paper from a set of articles proposed in advance. Questions and discussion during and after the presentation will be encouraged.

Intended Audience:

• students within the Cogmaster program
• students with a quantitative background (physics, computer science, mathematics, engineering etc.) that are interested in neuroscience
• students with a biology/neuroscience background that are interested in quantitative (mathematical) approaches to neuroscience

Validation:

Each week will be dedicated to one research article (see choice of articles below; please write to boubenec at ens dot fr to get a copy of these articles). This article will be presented by a student in a short talk (about 30 minutes), followed by a discussion among the students. To ensure a lively discussion, every student has to read the article and submit a question about it one week in advance. Students in the course will be judged by the talk they give (50%) and their participation in the discussions of all the other talks (50%).

Course Language:
The course languages will be French and English. Talks can be held in either language.

Time-location:
Tuesday 10h30-12h30 (07/03 → 30/06) / salle Théodule Ribot (29 rue d'Ulm)

Coordination-organization:
Yves Boubenec
Participant: Karim Benchenane, Yves Boubenec, Srdjan Ostojic, Shihab Shamma

2017 schedule:
― 21 mars : Danilo Lombardo
Rodgers and de Weese, 2014
― 28 mars : Sophie Baltassis
Tsunada et al., 2016
― 4 avril : Jeff Boucher
Hanks et al., 2015
― 18 avril : Gabrielle Tissot
Latimer et al., 2016
― 25 avril : Garance Merholz-Revel
Suzuki and Gottlieb, 2013
― 2 mai : Theo Desbordes
Stokes et al., 2013
― 9 mai : Kevin Thomas
Donahue et al., 2015
― 16 mai : Gaïa Ozeray
Liu et al., 2014
List of articles:

• Does seeing a decision signal in a brain area involve a causal role in decision? (I)
Dissociated functional significance of decision-related activity in the primate dorsal stream. Katz et al., 2016

• Does seeing a decision signal in a brain area involve a causal role in decision? (II)
Distinct relationships of parietal and prefrontal cortices to evidence accumulation. Hanks et al., 2015

• To which extent high-order brain areas multiplex task-related signals?
Encoding and decoding in parietal cortex during sensorimotor decision-making. Park et al., 2014

• How does population code change in sensory cortices during learning?
Pathway-specific reorganization of projection ne urons in somatosensory cortex during learning. Chen et al, 2015

• What about learning without PFC?
Medial prefrontal activity during delay period contributes to learning of a working memory task. Liu et al., 2014

• Can we find decision in sensory cortex?
Causal contribution of primate auditory cortex to auditory perceptual decision-making. Tsunada et al., 2016

• How do we go from a sensory representation to a subjective decision?
Neural correlate of subjective sensory experience gradually builds up across cortical areas. de Lafuente et Romo, 2006

• How do we get rid of distractors?
Distinct neural mechanisms of distractor suppression in the frontal and parietal lobe. Suzuki and Gottlieb, 2013

• Where and when does the brain encode and interpret a task?
Cortical information flow during flexible sensorimotor decisions. Siegel et al., 2015

• How is context maintained in memory?
Dynamic coding for cognitive control in prefrontal cortex. Stokes et al., 2013

• How do we switch between rules?
Neural correlates of task switching in prefrontal cortex and primary auditory cortex in a novel stimulus selection task for rodents. Rodgers and de Weese, 2014

• How do you decide in a changing world?
Deliberation and Commitment in the Premotor and Primary Motor Cortex during Dynamic Decision Making. Thura and Cisek, 2014

• Is prefrontal cortex a complete mess?
Natural grouping of neural responses reveals spatially segregated clusters in prearcuate cortex. Kiani et al., 2015

• How does learning settle top-down modulations in sensory cortex?
Learning enhances the relative impact of top-down processing in the visual cortex. Makino and Komiyama, 2016

• What about performing without PFC?
Lesions of prefrontal cortex reduce attentional modulations of neuronal resonses and synchrony in V4 Gregoriou et al., 2014

• Can we find all task-related information in PFC?
Dynamic routing of task-relevant signals for decision-making in dorsolateral prefrontal cortex Donahue et al., 2015

• What is the dynamics in parietal cortex during decision-making?
Single-trial spike trains in parietal cortex reveal discrete steps during decision-making Latimer et al., 2016

Introductory session:
• Presentation instructions (pdf)
• Basics about attention and decision-making in parietal and frontal cortices (pdf)